The article describes the pathological changes in the excretory system of the Central Asian turtle. The material of the study is a puncture biopsy of the kidneys obtained under ultrasound control, assessment of the morphological structure of kidneys using classical histological techniques, and biochemical analysis. As a result violations of mineral metabolism and kidney function are revealed. When histological examination using hematoxylin-eosin staining, hyperplasia of the perivascular connective tissue of kidneys, overgrowth of the lymphoid ducts, hypertrophy and edema of the renal glomerulus, rupture of the Bowman capsule, which characterizes the chronic course of the disease is noted.