In 2015, 18 sows of a large white breed, 72 piglets obtained from these sows and 18 boars from another farm, whose sperm was taken for fertilization of sows, were examined in the Kislov individual entrepreneur farm by resistance indicators. On the basis of blood indices, a new selection index of resistance was developed, which includes bactericidal, complementary and lysozyme activity of blood serum, phagocytic activity and index, taking into account the coefficients of heritability of each feature. Parent pairs were selected for resistance indices, which had a positive effect.