The productivity of crop rotation on soddy podzolic loam soil in the stationary experience during 2015-2017 was high in the conditions of the Vologda region, especially among annual crops. Winter rye and potatoes also differed by consistently high yield and productivity during the years of research. All the studied cultures showed good responsiveness to fertilizers, especially the calculated doses of their application. The average productivity of crop rotation was 3.30-6.34 tonne cu / ha. Minimum doses of fertilizers increased the productivity of crops by 1.02 tons of cu / ha, and calculated ones - by 72-90% compared with the control. Removal of nutrients with crop yields increased with the use of fertilizers. Different doses of fertilizers increased the removal of nitrogen 1.4-2.3 times, phosphorus - 1.4-2.0 times and potassium 1.4-2.5 times compared with the control. Calculated doses of fertilizers provided the greatest removal of nutrients, because the yield on these options was significantly higher than on the control and when using fertilizers only during sowing and planting. This affected the balance of nutrients in the soil. KB of nitrogen, phosphorus and potassium were higher than the planned values, respectively, by 15-34%, 23-36 and 12-21%. When fertilizers were applied on average for crop rotation in doses of 93kg AI / ha of nitrogen, 41 phosphorus and 136-165 kg AI / ha of potassium, respectively, a negative balance of nutrients was observed.