The results of field research conducted on soddy-podzolic light loam soil in the Vologda region established that the use of fertilizers significantly increased the yield of winter rye grain both against the background of the flavobacterin biofungicide and without its use. Depending on the doses of fertilizers and bacterialization with a microbiological preparation, the productivity of straw of winter rye naturally increased, the content of nitrogen, phosphorus, potassium in the production increased, the collection of crude protein by grain and the productivity in feed units increased.