Studies were conducted to determine the relationship between the method of breeding, the reproductive qualities of heifers and their subsequent milk productivity in the conditions of enterprises of the Omsk region. It was found that the best characteristics of reproductive qualities are heifers with an inbreeding coefficient of up to 6.25% or with moderate inbreeding and inseminated from 13 to 18 months of age. With increasing homozygosity of organisms, the level of milk productivity decreases. Outbred first-born heifers inseminated before 18 months of age exceed inbred female peers in milk yield by 350 kg or 5.96 %.