As a result of complex investigations conducted in the Tver region in 2013-2015 on well-cultivated soddy medium podzolic sandy loam soil the peculiarities of forming bio-resistance and productivity in three potato varieties (Lyubava, Krasavchik, Nikulinskiy) under the influence of foliar dressings with AgBion-2 and NanoGro preparations having different working liquid concentrations have been studied. It has been revealed that for increasing potato resistance to harmful objects, foliar dressings with AgBion-2 and NanoGro preparations should be included into the technological scheme of potatoes cultivation. It will significantly reduce the number of weeds and the number of leaf and tuber diseases To get the early harvest of high quality potatoes it is recommended to cultivate the early potato variety named Lyubava and spray it in the beginning of the budding phase with Nano-Gro nanomaterial in the dose of 25 pellets/ ha, that provides the yield of tubers on the level of 26.97 t/ha with 4.02 tons of starch per hectare. To get the largest yield of high-quality tubers for long-term storage it is also recommended to cultivate the medium potato variety named Nikulinskiy using the foliar dressing of AgBion-2 nanosilver with 0.15% concentration which ensures the yield of potatoes of 30 t/ha and allows getting 5.75 tons of starch per hectare, 0.75 tons of crude protein per hectare and the least content of nitrates and heavy metals in the product.